Following the death of M's bodyguard and Quantum employee, Craig Mitchell, MI6 forensically examines the late operative's personal affects. Examining the contents of Mitchell's wallet, they find marked notes which had been introduced by MI6 into Quantum financier Le Chiffre's money-laundering operation.
Bills from the same series as Mitchell's were recently scanned at a bank in Port-au-Prince, Haiti, and deposited in the account of a "Mr. Slate". They connect this to Edmund Slate, a gentleman returning to Port-au-Prince from Heathrow and staying in room 325 of the Hotel Dessalines.
James Bond is sent to the Hotel Dessalines to intercept Slate. Breaking into room 325, Bond is set upon by the knife-wielding hitman. After a vicious brawl, Slate is stabbed in the neck and endures a slow death.