Isthmus City is a fictional city in the 1989 film Licence to Kill.
- Isthmus is a reference to the real country of Panama which lies on an isthmus and the corrupt dictator Manuel Noriega, whom the CIA were working very hard to oust, at the time. He was eventually deposed by U.S. troops in the same year this film was released. *
- The flag of Isthmus bears a strong resemblance to the flag of Guatemala.
- The scenes for the city were shot in Mexico City.