Scarpine is introduced to James Bond under the alias of St. John Smythe, who arrived at the security check with Pan Ho. He tells Bond all the necessary information about what events will be taking place at the horse sale and even takes him to the showing. He then sends Bond on his way to the guest quarters, where he is met by Jenny Flex.
Scarpine is later seen at the party, when Bond uses his polarizing sunglasses to see inside Zorin's office to spy on his meeting with Stacey.
Later, Scarpine helps Zorin assassinate all the miners in the abandoned mine at the end of the film. He escapes the mine with Zorin and Hans Glaub, another henchman and a former Nazi scientist mentor of Zorin, and the chief pilot of the aircraft in flight.
After Bond throws Zorin from the Golden Gate Bridge, Scarpine and Glaub are killed while fighting over a lit stick of dynamite, which explodes in Zorin's blimp.